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Science & Technologies

Scientific Publications
  1. Fletcher, Simon P.; Steffy, Kevin R.; Averett, Devon R. Masked Oral Prodrugs of Toll-Like Receptor 7 Agonists: A New Approach for the Treatment of Infectious Diseases, Current Opinion in Investigational Drugs, 2006, 2006 7(8):702-708.
  2. Horsmans, Yves; Berg, Thomas; Desager, Jean-Pierre; Mueller, Tobias; Schott, Eckart; Fletcher, Simon P.; Steffy, Kevin R.; Bauman Lisa A.; Kerr, Bradley M.; Averett, Devron R. Isatoribine, an Agonist of TLR7, Reduces Plasma Virus Concentration in Chronic Hepatitis C Infection, Hepatology 2005, 42(2), 724-731.
  3. Hermann, Thomas. Drugs targeting the ribosome, Current Opinion in Structural Biology 2005, 15(3), 355-366.
  4. Hewitt, Robin; Gobbi, Alberto; Lee, Man-ling. A Searching and Reporting System for Relational Databases Using a Graph-Based Metadata Representation, Journal of Chemical Information Model. 2005, 45, 863-869
  5. Han, Qing; Zhao, Qiang; Fish, Sarah; Simonsen, Klaus B.; Vourloumis, Dionisios; Froelich, Jamie M.; Wall, Daniel; Hermann, Thomas. Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex, Angewandte Chemie International Edition 2005, 44(18), 2694-2700.
  6. Ayida, Benjamin K.; Simonsen, Klaus B.; Vourloumis, Dionisios; Hermann, Thomas. Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics, Bioorganic & Medicinal Chemistry Letters 2005, 15(10), 2457-2460.
  7. Yaroshevsky-Glanville, Mary. Conflict resolution in the biotech industry, Nature Biotechnology 2005, 23(3), 391-392.
  8. Hermann, Thomas; Tor, Yitzhak. RNA as a target for small-molecule therapeutics, Expert Opinion on Therapeutic Patents 2005, 15(1), 49-62.
  9. Vourloumis, Dionisios; Winters, Geoffrey C.; Simonsen, Klaus B.; Takahashi, Masayuki; Ayida, Benjamin K.; Shandrick, Sarah; Zhao, Qiang; Han, Qing; Hermann, Thomas. Aminoglycoside-hybrid ligands targeting the ribosomal decoding site, ChemBioChem 2005, 6(1), 8-65.
  10. Doundoulakis, Thomas; Xiang, Alan X.; Lira, Ricardo; Agrios, Konstantinos A.; Webber, Stephen E.; Sisson, Wes; Aust, Robert M.; Shah, Amit M.; Showalter, Richard E.; Appleman, James R.; Simonsen, Klaus B. Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation, Bioorganic & Medicinal Chemistry Letters 2004, 14(22), 5667-5672.
  11. Zhou, Yuefen; Murphy, Douglas E.; Sun, Zhongxiang; Gregor, Vlad E. Novel parallel synthesis of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides, Tetrahedron Letters 2004, 45(43), 8049-8051.
  12. Yaroshevsky-Glanville, Mary. Careers and recruitment: Strategic HR for today's biotechnology companies, Nature Biotechnology 2004, 22(9), 1189.
  13. Ovenden, Simon P.B; Sberna, Gian; Tait, R. Murray; Wildman, Howard G.; Patel, Rupal; Li, Bin; Steffy, Kevin; Nguyen, Natalie; Meurer-Grimes, Barbara M. A Diketopiperazine Dimer from a Marine-Derived Isolate of Aspergillus niger, Journal of Natural Products 2004, 67, 2093-2095.
  14. Shandrick, Sarah; Zhao, Qiang; Han, Qing; Ayida, Benjamin K.; Takahashi, Masayuki; Winters, Geoffrey C.; Simonsen, Klaus B.; Vourloumis, Dionisios; Hermann, Thomas. Monitoring molecular recognition of the ribosomal decoding site, Angewandte Chemie International Edition 2004, 43(24), 3177-3182.
  15. Gobbi, Alberto; Funeriu, Sandra; Ioannou, John; Wang, Jinyi; Lee, Man-Ling; Palmer, Chris; Bamford, Bob; Hewitt, Robin. Process-Driven Information Management System at a Biotech Company: Concept and Implementation, Journal of Chemical Information and Computer Sciences 2004, 44(3), 964-975.
  16. Barluenga, Sofia; Simonsen, Klaus B.; Littlefield, Ethel S.; Ayida, Benjamin K.; Vourloumis, Dionisios; Winters, Geoffrey C.; Takahashi, Masayuki; Shandrick, Sarah; Zhao, Qiang; Han, Qing; Hermann, Thomas. Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome, Bioorganic & Medicinal Chemistry Letters 2004, 14(3), 713-718.
  17. Simonsen, Klaus B.; Ayida, Benjamin K.; Vourloumis, Dionisios; Winters, Geoffrey C.; Takahashi, Masayuki; Shandrick, Sarah; Zhao, Qiang; Hermann, Thomas. Piperidine glycosides targeting the ribosomal decoding site, ChemBioChem 2003, 4(9), 886-890.
  18. Vourloumis, Dionisios; Winters, Geoffrey C.; Takahashi, Masayuki; Simonsen, Klaus B.; Ayida, Benjamin K.; Shandrick, Sarah; Zhao, Qiang; Hermann, Thomas. Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site, ChemBioChem 2003, 4(9), 879-885.
  19. Hermann, Thomas. Chemical and functional diversity of small molecule ligands for RNA, Biopolymers 2003, 70(1), 4-18.
  20. Vourloumis, Dionisios; Takahashi, Masayuki; Simonsen, Klaus B.; Ayida, Benjamin K.; Barluenga, Sofia; Winters, Geoffrey C.; Hermann, Thomas. Solid-phase synthesis of benzimidazole libraries biased for RNA targets, Tetrahedron Letters 2003, 44(14), 807-2811.
  21. Gobbi, Alberto; Lee, Man-Ling. DISE: Directed Sphere Exclusion, Journal of Chemical Information and Computer Sciences 2003, 43(1), 317-323.
  22. Lanford, Robert E.; Guerra, Bernadette; Lee, Helen; Averett, Devron R.; Pfeiffer, Brad; Chavez, Deborah; Notvall, Lena; Bigger, Catherine. Antiviral Effect and Virus-Hose Interactions in Response to Alpha Interferon, Gamma Interferon, Poly (I)-Poly(C), Tumor Necrosis Factor Alpha, and Ribavirin in Hepatitis C Virus Subgenomic Replicons, Journal of Virology, 2003, 77(2), 1092-1104.
  23. Basbaum, Andre. Anadys Pharmaceuticals, Inc., Pharmacogenomics 2003, 4(4), 511-8.
  24. Simonsen, Klaus B.; Ayida, Benjamin K.; Vourloumis, Dionisios; Takahashi, Masayuki; Winters, Geoffrey C.; Barluenga, Sofia; Qamar, Seema; Shandrick, Sarah; Zhao, Qiang; Hermann, Thomas. Novel paromamine derivatives exploring shallow-groove recognition of ribosomal-decoding-site RNA, ChemBioChem 2002, 3(12), 1223-1228.
  25. Hermann, Thomas. Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition, Biochimie 2002, 84(9), 869-875.
  26. van Buren, Bernd N.M.; Hermann, Thomas; Wijmenga, Sybren S.; Westhof, Eric. Brownian-dynamics simulations of metal-ion binding to four-way junctions, Nucleic Acids Research 2002, 30(2), 507-514.
  27. Vourloumis, Dionisios; Takahashi, Masayuki; Winters, Geoffrey C.; Simonsen, Klaus B.; Ayida, Benjamin K.; Barluenga, Sofia; Qamar, Seema; Shandrick, Sarah; Zhao, Qiang; Hermann, Thomas. Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA, Bioorganic & Medicinal Chemistry Letters 2002, 12(23), 3367-3372.
  28. Li, Bin; Wang, Mei Mei. Tutorial: uHTS-ATLAS for Affinity-Based Screening, Genetic Engineering News, 2002, 22(14), 36.
  29. Buurman, Ed T.; Jiang, Weidong; McCoy, Melissa; Averett, Devron R.; Thompson, Craig M.; Wobbe, C. Richard. Validation of Cdc68p as a novel antifungal target, Archives of Microbiology 2002, 178(6), 428-436.
  30. Buurman, Ed T.; Bradley, John D.; Donnelly, Caroline E.; Moore, Jeffrey B.; Healy, Judith M.; Averett, Devron R.; Thompson, Craig M.; Wobbe, C. Richard. Regulation of both gene expression and protein stability provides genetically assisted target evaluation (GATE) for microbial target validation, Pharmacogenomics 2001, 2(2), 95-106.


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